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The four-disulfide construct shown is called a WAP domain, named after whey acidic proteins which contain this core element. Other proteins with this domain have been described in humans, including HE4, previously thought to be similar to other WAP-containing proteins which probably function as protease inhibitors in the male reproductive system. A number of studies have indicated that HE4 is over-expressed in ovarian tumors, and a commercially available immunoassay for this marker has been developed. Recent evidence has also indicated HE4 expression in a number of tumor cell lines, including breast, colon and melanoma